Magnesium Complex 120’s

The Role of Nutrients in the Magnesium Complex Capsule:

Magnesium Complex provides a highly bioavailable form of magnesium bisglycinate, essential for muscle relaxation, bone health, energy production, and nervous system support. Magnesium plays a vital role in over 300 enzymatic reactions, particularly those involved in muscle function and energy metabolism. The inclusion of key vitamins such as C, D3, E, and B-complex, alongside minerals like zinc, copper, manganese, and selenium, enhances magnesium’s function by supporting immune health, promoting calcium absorption, and providing antioxidant protection. Vitamin D3 further supports bone health, while zinc and selenium contribute to DNA synthesis and immune cell performance.

Additionally, amino acids like L-Theanine and L-Glutamine aid in muscle recovery, stress reduction, and gut health. This synergistic blend of nutrients ensures optimal magnesium function, promotes a balanced immune system, and enhances overall vitality and well-being, helping the body defend against stressors and maintain long-term health.

Types of Magnesium:

Here’s a table summarizing the different types of magnesium, their functions, and bioavailability:

The Function of Magnesium in the body
Magnesium is a vital mineral that plays numerous critical roles in the body, including:

• Anti-inflammatory Action: Magnesium has anti-inflammatory properties, which can help reduce inflammation in the body and lower the risk of chronic conditions like heart disease and arthritis.
• Blood Sugar Regulation: It supports insulin activity and helps regulate blood sugar levels, making it crucial for glucose metabolism and reducing the risk of insulin resistance.
• Bone Health: Magnesium is essential for bone formation and influences the activity of osteoblasts (cells that build bone) and osteoclasts (cells that break down bone). It also helps regulate calcium and vitamin D levels, which are critical for maintaining bone density.
• DNA and Protein Synthesis: It is involved in the synthesis of DNA and RNA, as well as the production of proteins, which are essential for growth, repair, and maintenance of tissues.
• Electrolyte Balance: Magnesium helps maintain electrolyte balance by regulating other minerals such as sodium, potassium, and calcium, ensuring proper nerve signaling and muscle function.
• Energy Production: Magnesium is involved in the production of ATP, the body’s primary energy molecule. It helps convert food into energy and supports the metabolism of carbohydrates, fats, and proteins.
• Heart Health: Magnesium helps regulate heartbeat by maintaining the electrical balance required for proper heart rhythm and supporting the relaxation of blood vessels, which can lower blood pressure.
• Muscle Function: It regulates muscle contraction and relaxation by controlling calcium levels in muscle cells. This is important for preventing muscle cramps and maintaining smooth muscle function, including that of the heart.
• Nervous System Support: It plays a key role in neurotransmitter function and nerve transmission, contributing to calmness and relaxation by regulating neurotransmitters like GABA that control mood and sleep.

Overall, magnesium is fundamental for maintaining overall health, particularly in muscle and nerve function, energy production, cardiovascular health, and bone strength.
Magnesium deficiency symptoms

Here are some common signs of magnesium deficiency:

• Fatigue: Magnesium deficiency can cause fatigue and a general feeling of tiredness or lack of energy, as magnesium is essential for energy production.
• High Blood Pressure: Magnesium helps regulate blood pressure, so deficiency can lead to elevated blood pressure or worsen hypertension.
• Irregular Heartbeat: Severe magnesium deficiency can cause arrhythmia (irregular heartbeat), which can be serious and lead to complications.
• Mood Changes: Low magnesium levels are associated with mood disorders such as anxiety, irritability, and depression.
• Muscle Cramps and Spasms: Inadequate magnesium levels can lead to frequent muscle cramps, twitches, or spasms, particularly in the legs.
• Nausea and Vomiting: Some people with low magnesium levels may experience nausea, vomiting, or loss of appetite.
• Numbness and Tingling: Magnesium deficiency can cause tingling or numbness, particularly in the hands and feet, due to its role in nerve function.
• Osteoporosis: Chronic magnesium deficiency may contribute to bone thinning and osteoporosis, as magnesium is involved in bone formation and calcium metabolism.
• Restless Leg Syndrome: A deficiency in magnesium may be linked to restless leg syndrome, characterized by an uncontrollable urge to move the legs, often accompanied by discomfort.
• Sleep Problems: Difficulty sleeping, or insomnia can occur due to magnesium’s role in regulating neurotransmitters that help promote relaxation and sleep.
• Weakness: Muscle weakness or a feeling of reduced physical strength may occur due to insufficient magnesium affecting muscle function.

If you suspect magnesium deficiency, it’s important to consult with a healthcare professional for proper diagnosis and treatment.

The interaction of other vitamins, minerals and amino acids on the working of a magnesium supplement

Magnesium is a vital mineral involved in hundreds of biochemical reactions in the body, supporting muscle function, energy production, and bone health. However, the effectiveness of magnesium is significantly enhanced when paired with complementary vitamins, minerals, and amino acids. These nutrients work synergistically to improve magnesium absorption, optimize its role in cellular processes, and amplify its benefits for the nervous system, immune function, and cardiovascular health. Below is an overview of how each nutrient interacts with magnesium to boost its efficacy and promote overall well-being.

• Amino Acids (L-Theanine, L-Glutamine): Magnesium and amino acids such as L-Theanine and L-Glutamine work together to support nervous system function, reduce stress, and enhance muscle recovery. Magnesium aids in the metabolism of these amino acids, promoting tissue repair, protein synthesis, and overall muscle and cognitive health.
• Calcium: Magnesium and calcium work together to regulate muscle contraction and relaxation, with magnesium preventing calcium overload in cells. This balance is crucial for muscle relaxation and bone health, as magnesium ensures calcium is properly deposited in bones rather than soft tissues, thereby helping to prevent muscle cramps and reducing the risk of calcification in arteries.
• Copper: Copper supports magnesium in enzymatic functions crucial for energy production, connective tissue formation, and antioxidant defense. Magnesium, in turn, stabilizes copper’s role in maintaining cardiovascular health, regulating the nervous system, and enhancing immune function, ensuring balanced energy levels and overall well-being.
• Fulvic Acid: Fulvic acid enhances the bioavailability of magnesium by improving its absorption and transport across cell membranes. This increased absorption allows magnesium to more effectively support energy production, detoxification, and cellular health, ensuring optimal nutrient utilization and overall wellness.
• Manganese: Manganese and magnesium both function as cofactors in enzymatic processes related to bone formation, collagen synthesis, and antioxidant defense. Together, they enhance bone strength, protect against oxidative damage, and support joint and tissue integrity by improving the body’s antioxidant capacity.
• Potassium: Magnesium and potassium regulate cellular fluid balance, nerve transmission, and muscle contractions. Magnesium helps maintain adequate potassium levels within cells, promoting proper nerve function, reducing muscle cramps, and supporting cardiovascular health, particularly in maintaining regular heart rhythms.
• Selenium: Selenium and magnesium work together in antioxidant defense, with magnesium supporting selenium-dependent enzymes like glutathione peroxidase. This synergy reduces oxidative stress, supports immune function, and promotes cardiovascular and cellular health, particularly by protecting against inflammation and free radical damage.
• Taurine: Taurine and magnesium synergistically regulate calcium flow within cells, promoting muscle relaxation, stable heart function, and electrolyte balance. Both nutrients contribute to cardiovascular health, reduce stress on the nervous system, and support muscle endurance and cellular stability.
• Vitamin B6 (Pyridoxine): Vitamin B6 improves magnesium absorption at the cellular level and activates magnesium-dependent enzymes involved in energy production and neurotransmitter synthesis. It also prevents magnesium excretion through the kidneys, ensuring that magnesium’s benefits for muscle function, nervous system health, and energy metabolism are maximized.
• Vitamin C: Vitamin C and magnesium collaborate in antioxidant protection, reducing oxidative stress in cells and supporting collagen synthesis for tissue repair. Magnesium helps maintain proper cellular energy levels, while vitamin C enhances magnesium’s immune-boosting and cardiovascular protective effects, contributing to overall health and vitality.
• Vitamin D: Vitamin D enhances magnesium absorption in the intestines and plays a role in regulating calcium metabolism. Magnesium, in turn, is essential for converting vitamin D into its active form, calcitriol. This interaction supports bone health, immune function, and overall calcium balance, optimizing both nutrients’ effects on the body.
• Vitamin K2: Vitamin K2 helps direct calcium to bones while preventing it from depositing in arteries, working in synergy with magnesium to maintain proper calcium utilization. Magnesium supports K2’s role in balancing calcium and promoting cardiovascular and bone health, reducing the risk of calcification and improving bone density.
• Zinc: Magnesium and zinc complement each other in various enzymatic reactions and cellular processes. Zinc supports magnesium-dependent enzymes involved in immune function, protein synthesis, and energy production. Together, they help improve muscle relaxation, enhance immune defense, and optimize metabolic processes.

Ingredients which are traditionally used for this disorder
Technical info:

Ashwagandha: Contains withanolides, steroidal lactones that exhibit adaptogenic, anti-inflammatory, and immunomodulatory properties. Ashwagandha helps regulate the hypothalamic-pituitary-adrenal (HPA) axis, reducing cortisol levels, improving stress resilience, and enhancing immune response. It also supports mitochondrial health and cognitive function through neuroprotective actions.

Black Pepper: Contains piperine, which enhances the bioavailability of various nutrients by inhibiting intestinal glucuronidation and hepatic metabolism. Piperine modulates drug-metabolizing enzymes such as CYP450 and exhibits anti-inflammatory, antioxidant, and antitumor properties by reducing the production of pro-inflammatory cytokines and free radicals.

Boron Glycinate: Boron acts as a regulator of mineral metabolism, enhancing the absorption of calcium and magnesium, and modulates steroid hormone levels such as estrogen and testosterone. It also supports bone matrix integrity and reduces markers of inflammation through its involvement in antioxidant enzyme activity.

Calcium Carbonate: Provides elemental calcium critical for bone matrix deposition, muscle contraction, nerve signal transmission, and enzymatic activity. Calcium carbonate increases bone mineral density and modulates intracellular signaling pathways such as calcium-mediated neurotransmitter release and muscle contraction, essential in preventing osteoporosis and supporting cardiovascular function.

Chromium: A trace mineral that enhances the function of insulin by potentiating insulin receptor activity, thereby improving glucose uptake via GLUT4 translocation. Chromium regulates lipid metabolism and decreases hyperglycaemia-induced oxidative stress by modulating insulin activity and enhancing energy metabolism.

Co-Enzyme Q10: An essential component of the mitochondrial electron transport chain, CoQ10 facilitates oxidative phosphorylation for ATP production. CoQ10 also acts as a potent antioxidant, reducing mitochondrial oxidative stress and lipid peroxidation, supporting cardiovascular health, and improving endothelial function in ischemic and hypertensive conditions.

Copper Bisglycinate: Copper is an essential trace element involved in enzymatic processes such as cytochrome c oxidase in mitochondrial respiration, lysyl oxidase in collagen cross-linking, and superoxide dismutase in antioxidant defense. Copper also supports iron absorption and transport, immune function, and maintenance of neurological and cardiovascular health.

Folic Acid (Vit B9): Folic acid is a key cofactor in one-carbon metabolism, facilitating the conversion of homocysteine to methionine via methionine synthase, thereby supporting DNA methylation, red blood cell production, and reducing the risk of cardiovascular diseases. Folic acid also plays a critical role in nucleotide biosynthesis during cell division.

Fulvic Acid: A bioactive humic substance that acts as a chelator of trace minerals, fulvic acid enhances nutrient absorption at the cellular level and exhibits significant antioxidant and anti-inflammatory properties. It facilitates detoxification by binding to heavy metals and free radicals, enhancing cellular energy production and supporting the immune response.

Ginger: Contains bioactive phenolic compounds such as gingerol and shogaol, which possess anti-inflammatory, antioxidant, and antiemetic properties. Ginger reduces prostaglandin synthesis and modulates inflammatory pathways by inhibiting COX-2 and TNF-α, making it beneficial in gastrointestinal disorders, inflammatory conditions, and pain management.

Gingko Biloba: Contains flavonoids and terpenoids that improve cerebral and peripheral microcirculation by enhancing nitric oxide production and inhibiting platelet-activating factor. Gingko also exhibits neuroprotective effects by reducing oxidative stress and inflammation, which is beneficial in cognitive decline, memory impairment, and neurodegenerative conditions.

L-Glutamine: A conditionally essential amino acid that serves as a critical energy source for rapidly proliferating cells, such as enterocytes and lymphocytes. L-glutamine supports the integrity of the gut barrier, enhances immune function, and facilitates protein synthesis and nitrogen balance, particularly during stress and recovery phases.

L-Theanine: An amino acid found primarily in tea leaves, L-theanine modulates alpha brain wave activity, promoting relaxation and reducing stress without sedation. It also influences neurotransmitter levels, including GABA, serotonin, and dopamine, enhancing cognitive performance and improving mental clarity.

Magnesium Bisglycinate: A highly bioavailable form of magnesium chelated with glycine, essential for over 300 enzymatic reactions, including ATP production, DNA synthesis, and neurotransmitter release. Magnesium bisglycinate reduces neuromuscular excitability, regulates calcium channel function, and plays a key role in cardiovascular health, reducing hypertension and arrhythmias.

Manganese: Manganese is a vital cofactor for antioxidant enzymes, particularly mitochondrial superoxide dismutase (MnSOD), protecting cells from oxidative stress. It is also essential for collagen formation, bone mineralization, and wound healing, as well as for carbohydrate and lipid metabolism through activation of various enzymes.

Parsley: Rich in vitamins A, C, K, and flavonoids, parsley exhibits diuretic, antioxidant, and anti-inflammatory properties. It enhances detoxification pathways, supports kidney and liver function, and provides antioxidant protection by scavenging free radicals through the action of apigenin and luteolin.

Potassium Citrate: An essential electrolyte that helps regulate acid-base balance, neuromuscular function, and fluid balance. Potassium supports cardiovascular function by regulating blood pressure and counteracting the effects of sodium, while promoting the maintenance of muscle and nerve function.

Selenium: Selenium is a key component of selenoproteins such as glutathione peroxidase and thioredoxin reductase, which protect cells from oxidative damage. Selenium also supports thyroid hormone metabolism and immune function, particularly by regulating inflammation and reducing oxidative stress.

Taurine: A sulfur-containing amino acid that regulates calcium homeostasis, stabilizes cell membranes, and acts as an antioxidant. Taurine modulates neurotransmitter release, reduces oxidative stress, and supports cardiovascular function by improving endothelial function and reducing hypertension.

Turmeric: Contains curcumin, a polyphenolic compound with potent anti-inflammatory and antioxidant properties. Curcumin inhibits NF-κB, reducing the production of pro-inflammatory cytokines such as IL-6 and TNF-α, while also enhancing detoxification pathways via activation of Nrf2.

Vitamin A Acetate: A fat-soluble vitamin involved in regulating immune function, vision, and epithelial tissue integrity. Vitamin A supports mucosal immunity by promoting the differentiation of T and B cells and enhancing the integrity of epithelial barriers in the respiratory and gastrointestinal tracts.

Vitamin B1 (Thiamine): Thiamine, in its active form thiamine pyrophosphate (TPP), acts as a cofactor in glucose metabolism, particularly in the decarboxylation of pyruvate in the Krebs cycle. Thiamine is essential for ATP production, nerve conduction, and the synthesis of neurotransmitters like acetylcholine.

Vitamin B12: Cobalamin is a key cofactor in the synthesis of DNA, red blood cells, and the maintenance of nerve cells. Vitamin B12 is essential for the conversion of homocysteine to methionine, reducing cardiovascular risk and supporting cognitive function.

Vitamin B3 (Nicotinamide): Nicotinamide acts as a precursor for NAD+ and NADP+, critical coenzymes in redox reactions, DNA repair, and cellular energy production. It exhibits anti-inflammatory effects by modulating sirtuins and improving cellular energy metabolism, particularly in skin health and metabolic regulation.

Vitamin B5 (Calcium D-Pantothenate): A precursor to coenzyme A (CoA), which is necessary for fatty acid metabolism, acetylation reactions, and the synthesis of neurotransmitters. Vitamin B5 supports adrenal function, wound healing, and energy production in the citric acid cycle.

Vitamin B6 Pyridoxine: Pyridoxal phosphate, the active form of vitamin B6, is involved in over 100 enzymatic reactions, primarily in amino acid metabolism, neurotransmitter synthesis, and homocysteine regulation. Vitamin B6 supports cognitive function and immune health by promoting T-cell proliferation and reducing inflammation.

Vitamin C – Ascorbic Acid Powder: Ascorbic acid is a potent antioxidant that supports collagen synthesis, immune function, and wound healing. It neutralizes free radicals and regenerates other antioxidants like vitamin E, reducing oxidative stress and enhancing the immune response to infections.

Vitamin D3 Cholecalciferol: Cholecalciferol is converted to calcitriol, the active form of vitamin D, which regulates calcium and phosphate absorption, bone mineralization, and immune function. Vitamin D3 modulates the innate and adaptive immune responses by enhancing the production of antimicrobial peptides.

Vitamin E Alpha Tocopherol Acetate: A lipid-soluble antioxidant that protects polyunsaturated fatty acids within cell membranes from oxidative damage. Vitamin E supports cardiovascular health, reduces lipid peroxidation, and plays a critical role in immune function by protecting immune cells from oxidative stress.

Vitamin K2: Vitamin K2 is essential for the carboxylation of osteocalcin, promoting calcium deposition in bones and preventing arterial calcification. It works synergistically with vitamin D to support bone mineralization and cardiovascular health by regulating calcium metabolism.

Zinc: Combines zinc and vitamin C to enhance immune defense, wound healing, and reduce oxidative stress. Zinc is crucial for over 300 enzymatic processes, supporting DNA synthesis, cell division, and immune function.